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KMID : 0364019960290101055
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Korean Journal of Thoracic and Cardiovascular Surgery
1996 Volume.29 No. 10 p.1055 ~ p.1065
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The Effect of Nitric Oxide, Isosorbide Dinitrate and Sodium Nitroprusside on Ischemic Myocardium of Rat
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Abstract
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This experiment was undertaken to assess the effect of nitric oxide, isosorbide dinitrate, and sodium nitroprusside, which are known to increase coronary flow by vasodilation and to improve the cardiac function of an ischemic heart.
The experiment was carried out to investigate the effect of nitric oxide on the coronary artery of an ischemic rat myocardium using isolated constant pressure Langendorff system. The experimental parameters were lactate and CK-MB for the frozen
myocardium and coronary flow, the quantity of coronary flow, left ventricular developed pressure(LVDP), and dp/dt.
The experimental groups were devided as control group(Group I), nitric oxide group(Group II), isosorbide dinitrate group(Group III) and sodium nitroprusside group(Group IV). Statistical analysis was performed using repeated measured analysis of
variance
and Student T-test.
@ES The results were as follows:
@EN 1. The lactic acid contents of group II and IV were less than other groups for the frozen myocardium at preischemic state(p<0.0025), whereas the determined coronary flows were higher.
2. In the ratio of produced lactic acid between the preischemia and reperfusion for the coronary flow, group II and IV exhibited less value than others(p<0.005).
3. Group II and III were less than others in the coronary flow for the quantity of CK-MB, but for the frozen myocardium, group II and IV were less.
4. Group II and IV showed higher coronary flow compared to others throughout entire experimental period(p<0.005).
5. Group II was highest at the preischemic state for the left ventricular developed pressure.
6. The +maximal dp/dt of group II was highest compared to others.
7. Group I exhibited the highest recovery rate of coronary flow between preischemia and reperfusion.
8. The (-dp/dt)/(+dp/dt) ratio was 116%. 100%, 100%, and 55% for the 4 groups, respectively. And the recovery rate of total dp/dt was 34%, 67%, 51%, and 76% for the four groups, respectively.
In conclusion, nitric oxide was a significant agent inducing the dilatation of coronary vasculature. The quantities of lactic acid and CK-MB of Group II and IV were less than others. But the effect of increasing the LVDP was not higher than
others
at
the reperfusion state.
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KEYWORD
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